Journal
CELLULAR AND MOLECULAR LIFE SCIENCES
Volume 65, Issue 7-8, Pages 1220-1236Publisher
SPRINGER BASEL AG
DOI: 10.1007/s00018-008-7565-9
Keywords
serine proteases; enzyme catalysis; thrombin; allostery
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Funding
- NHLBI NIH HHS [HL 49413, HL 73813, HL 58141] Funding Source: Medline
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL049413, R01HL058141, R01HL073813, R29HL049413] Funding Source: NIH RePORTER
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Serine peptidases play key roles in human health and disease and their biochemical properties shaped the molecular evolution of these processes. Of known proteolytic enzymes, the serine peptidase family is the major cornerstone of the vertebrate degradome. We describe the known diversity of serine peptidases with respect to structure and function. Particular emphasis is placed on the S1 peptidase family, the trypsins, which underwent the most predominant genetic expansion yielding the enzymes responsible for vital processes in man such as digestion, blood coagulation, fibrinolysis, development, fertilization, apoptosis and immunity.
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