Journal
CELLULAR AND MOLECULAR LIFE SCIENCES
Volume 66, Issue 2, Pages 203-224Publisher
SPRINGER BASEL AG
DOI: 10.1007/s00018-008-8388-4
Keywords
ADAM; ADAMTS; fibrosis; MMP; plasminogen; skin; wound
Categories
Funding
- Academy of Finland [114409]
- Finnish Cancer Research Foundation
- Sigrid Juselius Foundation
- Turku University Central Hospital EVO [13336]
- European Union Framework Programme 6 [LSHC-CT-2003503297]
- Turku Graduate School of Biomedical Sciences
- Orion-Farmos Research Foundation
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Cutaneous wound healing is a complex and highly coordinated process where a number of different cell types participate to renew the damaged tissue under the strict regulation of soluble and insoluble factors. One of the most versatile processes involved in wound repair is proteolysis. During cell migration, proteins of extracellular matrix are cleaved, often creating biologically active cleavage products, and proteolysis of cellular contacts leads to increased cell motility and division. Moreover, proteases activate various growth factors and other proteases in wound and regulate growth factor signaling by shedding growth factor receptors on cell surface. Normally, proteolysis is strictly controlled, and changes in protease activity are associated with alterations in wound closure and scar formation. Here, we present the current view on the role of metalloproteinases and the plasmin-plasminogen system in normal and aberrant cutaneous wound repair and discuss their role as potential therapeutic targets for chronic ulcers or fibrotic scars.
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