Journal
CELLULAR AND MOLECULAR LIFE SCIENCES
Volume 65, Issue 18, Pages 2913-2923Publisher
SPRINGER BASEL AG
DOI: 10.1007/s00018-008-8263-3
Keywords
long-term depression; synaptic transmission; metabotropic glutamate receptors; AMPA receptors
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Glutamate, by activation of metabotropic receptors (mGluRs), can lead to a reduction of synaptic efficacy at many synapses. These forms of synaptic plasticity are referred to as long-term depression (mGluR-LTD). We will distinguish between mGluR-LTD induced by pre- or postsynaptic receptors and mGluR-LTD induced by the locus of the expression mechanism of the synaptic depression. We will also review recent evidence that mGluR-mediated responses themselves are subject to depression, which may constitute a form of metaplasticity.
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