Journal
CELLULAR AND MOLECULAR LIFE SCIENCES
Volume 65, Issue 24, Pages 4000-4018Publisher
SPRINGER BASEL AG
DOI: 10.1007/s00018-008-8357-y
Keywords
Sirtuin; deacetylase; longevity; human disease; therapeutics
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Funding
- Nestec SA
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Sirtuins comprise a unique class of nicotinamide adenine dinucleotide (NAD(+))-dependent deacetylases that target multiple protein substrates to execute diverse biological functions. These enzymes are key regulators of clinically important cellular and organismal processes, including metabolism, cell division and aging. The desire to understand the important determinants of human health and lifespan has resulted in a firestorm of work on the seven mammalian sirtuins in less than a decade. The implication of sirtuins in medically important areas such as diabetes, cancer, cardiovascular dysfunction and neurodegenerative disease has further catapulted them to a prominent status as potential targets for nutritional and therapeutic development. Here, we present a review of published results on sirtuin biology and its relevance to human disease.
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