Journal
CELLULAR AND MOLECULAR LIFE SCIENCES
Volume 65, Issue 12, Pages 1916-1932Publisher
SPRINGER BASEL AG
DOI: 10.1007/s00018-008-7573-9
Keywords
urokinase; urokinase receptor; uPAR; integrins; cancer
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Funding
- NCI NIH HHS [R01 CA125564] Funding Source: Medline
- NHLBI NIH HHS [HL44712] Funding Source: Medline
- NATIONAL CANCER INSTITUTE [R01CA125564] Funding Source: NIH RePORTER
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL044712] Funding Source: NIH RePORTER
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Enhanced levels of expression of urokinase receptor (uPAR) and certain integrins have been linked to cancer cell progression. This has classically been attributed to matrix degradation via the activation of the urokinase (uPA)/plasmin system and modulation of cell motility and survival through integrin engagement. More recently, uPAR has been shown to play multiple roles independent of protease activity. Specifically, uPAR has been shown to be intimately involved in the regulation of cell adhesion, migration and proliferation in part through interactions with other membrane partners, including integrins. The goal of this review is to summarize recent insights in the function of uPAR/integrin interactions, to provide a framework for understanding the importance of these interactions in the context of cancer, and to highlight its potential as a target for therapeutic intervention.
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