Journal
CELLULAR AND MOLECULAR LIFE SCIENCES
Volume 65, Issue 15, Pages 2289-2295Publisher
SPRINGER BASEL AG
DOI: 10.1007/s00018-008-8028-z
Keywords
odorant; sensory; GPCR; dimerization; receptor transporting protein; desensitization; surface; expression
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Olfactory receptors typically exhibit poor plasma membrane localization and functionality when heterologously expressed in most cell types. It has therefore proven difficult to effectively study olfactory receptor pharmacology and signaling mechanisms using traditional cell culture systems. Over the past few years, a variety of distinct proteins have been reported to interact with olfactory receptors and facilitate olfactory receptor trafficking to the plasma membrane in heterologous cells. Advances in this area have shed significant light on the fundamental factors governing the cell-specific control of olfactory receptor trafficking.
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