Journal
MECHANISMS OF AGEING AND DEVELOPMENT
Volume 123, Issue 2-3, Pages 177-193Publisher
ELSEVIER SCI IRELAND LTD
DOI: 10.1016/S0047-6374(01)00344-X
Keywords
caloric restriction; aging; gene expression; DNA microarrays; muscle; brain
Categories
Funding
- NATIONAL CANCER INSTITUTE [R01CA078723] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON AGING [P01AG011915, R01AG018922] Funding Source: NIH RePORTER
- NCI NIH HHS [R01 CA78723] Funding Source: Medline
- NIA NIH HHS [P01 AG11915, R01 AG18922] Funding Source: Medline
Ask authors/readers for more resources
We have previously employed high density oligonucleotide arrays representing thousands of genes to determine the gene expression profile of the aging process in skeletal muscle (gastrocnemius) and brain (cerebellum and neocortex) of male C57BL/6 mice. Specific gene expression profiles are associated with the aging process of individual organs, and caloric restriction can prevent or retard the establishment of these gene expression alterations. The use of DNA microarrays may provide a new toot to measure biological age on a tissue-specific basis and to evaluate at the molecular level the efficacy of interventions designed to retard the aging process. (C) 2002 Published by Elsevier Science Ireland Ltd.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available