Journal
CELLULAR AND MOLECULAR LIFE SCIENCES
Volume 65, Issue 7-8, Pages 1133-1149Publisher
SPRINGER BASEL AG
DOI: 10.1007/s00018-008-7472-0
Keywords
oxygen homeostasis; hypoxia; HIF signaling; physiopathology; therapy
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All organisms respond to changes in their environment by activating complex signaling cascades. The hypoxia-signaling cascade is activated in response to low oxygen availability and this activation is central to maintaining oxygen homeostasis and hence to survival. By regulating the transcriptional complex hypoxia-inducible factor, hypoxia is associated with several physiopathological processes. Several strategies, based on the targeting of the hypoxia-signaling cascade, have been developed to treat these pathologies. Our review summarize different aspects of the hypoxic pathway.
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