Journal
JOURNAL OF INTERFERON AND CYTOKINE RESEARCH
Volume 22, Issue 1, Pages 95-101Publisher
MARY ANN LIEBERT INC PUBL
DOI: 10.1089/107999002753452700
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Funding
- NATIONAL CANCER INSTITUTE [P01CA019014] Funding Source: NIH RePORTER
- NCI NIH HHS [CA 19014] Funding Source: Medline
- NIAID NIH HHS [AI 42372-01] Funding Source: Medline
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Interferon (IFN) regulatory factors (IRF) are a family of transcription factors with multiple functions. IRF-7 was initially cloned within the biologic context of Epstein-Barr virus (EBV) latency and discovered to have an intimate relation with the EBV primary oncogenic protein, latent membrane protein-1 (LMP-1). EBV regulates and uses IRF-7 as a secondary mediator for several target genes involved in latency and immune regulation. Other than its functions in EBV latency, IRF-7 has been identified as one of the major players in virally induced IFN production that is central to innate immunity. Thus, IRF-7 plays important roles in a variety of biologic systems.
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