Journal
CANCER CELL
Volume 4, Issue 5, Pages 383-391Publisher
CELL PRESS
DOI: 10.1016/S1535-6108(03)00273-3
Keywords
-
Categories
Funding
- NCI NIH HHS [P01 CA 82713, CA 30199, T32 CA77109-05] Funding Source: Medline
- NATIONAL CANCER INSTITUTE [P01CA082713, P30CA030199, T32CA077109] Funding Source: NIH RePORTER
Ask authors/readers for more resources
Phage display was used to identify homing peptides for blood vessels in a mouse model of HPV16-induced epidermal carcinogenesis. One peptide, CSRPRRSEC, recognized the neovasculature in dysplastic skin but not in carcinomas. Two other peptides, with the sequences CGKRK and CDTRL, preferentially homed to neovasculature in tumors and, to a lesser extent, premalignant dysplasias. The peptides did not home to vessels in normal skin, other normal organs, or the stages in pancreatic islet carcinogenesis in another mouse model. The CGKRK peptide may recognize heparan sulfates in tumor vessels. The dysplasia-homing peptide is identical to a loop in kallikrein-9 and may bind a kallikrein inhibitor or substrate. Thus, characteristics of the angiogenic vasculature distinguish premalignant and malignant stages of skin tumorigenesis.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available