Journal
MECHANISMS OF DEVELOPMENT
Volume 120, Issue 11, Pages 1283-1296Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.mod.2003.07.003
Keywords
phosphatidylinositol 3-kinase; target of rapamycin; cell growth; autophagy; morphogenesis; spindle orientation; Drosophila
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Funding
- NIGMS NIH HHS [R01 GM062509] Funding Source: Medline
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM062509] Funding Source: NIH RePORTER
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Growth of organisms and their constituent parts responds to both intrinsic and extrinsic cues during development: organisms of a given species generally grow at a predictable rate and to a specific body size, but individuals can modify this program during development in response to environmental conditions. Recent experiments, using gene knockouts and targeted overexpression, have revealed the central role of a signaling network controlled by the PI3K and TOR kinases in this regulation. These signaling molecules control growth by coordinately regulating a large number of cell biological processes. This review focuses on the cellular activities regulated by PI3K and TOR during development, and discusses how changes in different aspects of cellular metabolism may interact to regulate growth. (C) 2003 Elsevier Ireland Ltd. All rights reserved.
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