Journal
CELLULAR AND MOLECULAR BIOENGINEERING
Volume 2, Issue 1, Pages 49-56Publisher
SPRINGER
DOI: 10.1007/s12195-009-0049-7
Keywords
Indentation; Elastic; Viscoelastic; Membrane; Gel
Funding
- Centre for Trophoblast Research, University of Cambridge
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A series of bulk gels and free-standing membranes were fabricated from identical gelatin melts. Viscoelastic indentation load-relaxation tests were performed for both material geometries, where the indentation approximates a half-space for the bulk gels and a drumhead deformation test for the membranes. Elastic modulus values increased with gelatin concentration and gel strength and decreased with increasing indentation strain. There was more extensive load-relaxation in larger strain membranes. Numerical values of modulus were consistent between the two testing geometries, again exhibiting strain-dependent decreases. The membrane indentation method shows promise for characterizing the viscoelastic responses of biological tissue membranes and individual cells with potential application as a diagnostic technique.
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