Journal
TRENDS IN BIOCHEMICAL SCIENCES
Volume 28, Issue 12, Pages 639-645Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibs.2003.10.002
Keywords
-
Categories
Funding
- NIDDK NIH HHS [DK34854, DK48106, DK57827] Funding Source: Medline
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [R01DK048106, P30DK034854, R01DK057827, R37DK048106] Funding Source: NIH RePORTER
Ask authors/readers for more resources
Cholera toxin (CT) and related AB(5)-subunit toxins move from the plasma membrane through the trans-Golgi and endoplasmic reticulum (ER) to the cytosol of host cells. The toxins exploit a specific glycolipid pathway rather than a protein pathway. They bind glycolipids that associate with lipid rafts at the cell surface, which carry the toxins retrograde to the Golgi and ER. In the ER, the All-chain of the CT unfolds and enters the cytosol by hijacking the cellular machinery that enables misfolded proteins to cross the membrane for degradation by the proteasome, a process termed retro-translocation. Upon entering the cytosol, the All-chain rapidly refolds, avoids the proteasome and induces toxicity.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available