Journal
CELLULAR & MOLECULAR IMMUNOLOGY
Volume 10, Issue 4, Pages 286-288Publisher
CHIN SOCIETY IMMUNOLOGY
DOI: 10.1038/cmi.2013.15
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Funding
- Grants-in-Aid for Scientific Research [24591489] Funding Source: KAKEN
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The balance between follicular helper T cells (T-FH cells) and follicular regulatory T (Treg) cells (T-FR cells) is one of the key factors for the development of humoral immune responses. How the balance is regulated, however, is largely unknown. In a recent issue of Nature Immunology, Sage et al. revealed a critical role of the programmed death-1 (PD-1)/PD-L1 pathway in TFR cell generation and function, 1 which provides a novel insight into the mechanisms how T-FH and T-FR cells regulate antibody production.
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