Journal
CELLULAR & MOLECULAR IMMUNOLOGY
Volume 10, Issue 6, Pages 497-505Publisher
CHIN SOCIETY IMMUNOLOGY
DOI: 10.1038/cmi.2013.27
Keywords
asthma; bavachinin; IL-4
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Funding
- National Natural Science Foundation of China [30890143]
- Key Program for International S&T Cooperation Projects of China [2010DFB34000]
- National Basic Research Grant of China [2010CB529104]
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Asthmatic inflammation is mediated by a type 2 helper T cell (Th2) cytokine response, and blocking Th2 cytokine production is proven to have a potent therapeutic effect against asthmatic inflammation. Using IL-4-green fluorescent protein (GFP) reporter mice, we demonstrated that Bavachinin, a single compound isolated from a Chinese herb, significantly inhibited Th2 cytokine production, including IL-4, IL-5 and IL-13. Notably, this compound almost completely blocked inflammation in the ovalbumin (OVA)-sensitized animal asthma model. Furthermore, we demonstrated that this chemical selectively affects the level of GATA-3, most likely by affecting the stability of GATA-3 mRNA. Our results demonstrate, for the first time, the potential therapeutic value of this single compound derived from Chinese herbs.
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