Related references
Note: Only part of the references are listed.B cells lacking the tumor suppressor TNFAIP3/A20 display impaired differentiation and hyperactivation and cause inflammation and autoimmunity in aged mice
Yuanyuan Chu et al.
BLOOD (2011)
Keratinocyte-specific ablation of the NF-κB regulatory protein A20 (TNFAIP3) reveals a role in the control of epidermal homeostasis
S. Lippens et al.
CELL DEATH AND DIFFERENTIATION (2011)
Deubiquitinases in the regulation of NF-kappa B signaling
Edward W. Harhaj et al.
CELL RESEARCH (2011)
NF-kappa B signaling pathways regulated by CARMA family of scaffold proteins
Marzenna Blonska et al.
CELL RESEARCH (2011)
A20 deficiency in B cells enhances B-cell proliferation and results in the development of autoantibodies
Nadine Hoevelmeyer et al.
EUROPEAN JOURNAL OF IMMUNOLOGY (2011)
The Ubiquitin-Editing Protein A20 Prevents Dendritic Cell Activation, Recognition of Apoptotic Cells, and Systemic Autoimmunity
Mirjam Kool et al.
IMMUNITY (2011)
Polyubiquitin binding to ABIN1 is required to prevent autoimmunity
Sambit K. Nanda et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2011)
Direct, Noncatalytic Mechanism of IKK Inhibition by A20
Brian Skaug et al.
MOLECULAR CELL (2011)
Tumor suppressor TNFAIP3 (A20) is frequently deleted in Sezary syndrome
F. C. M. Braun et al.
LEUKEMIA (2011)
SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis
Fumiyo Ikeda et al.
NATURE (2011)
Linear ubiquitination prevents inflammation and regulates immune signalling
Bjoern Gerlach et al.
NATURE (2011)
A20 (TNFAIP3) deficiency in myeloid cells triggers erosive polyarthritis resembling rheumatoid arthritis
Mourad Matmati et al.
NATURE GENETICS (2011)
The kinase IKKα inhibits activation of the transcription factor NF-κB by phosphorylating the regulatory molecule TAX1BP1
Noula Shembade et al.
NATURE IMMUNOLOGY (2011)
Expression of A20 by dendritic cells preserves immune homeostasis and prevents colitis and spondyloarthritis
Gianna Elena Hammer et al.
NATURE IMMUNOLOGY (2011)
The E3 ligase Itch and deubiquitinase Cyld act together to regulate Tak1 and inflammation
Neesar Ahmed et al.
NATURE IMMUNOLOGY (2011)
TNFAIP3 Maintains Intestinal Barrier Function and Supports Epithelial Cell Tight Junctions
Lauren E. Kolodziej et al.
PLOS ONE (2011)
A20-binding inhibitor of NF-κB (ABIN1) controls Toll-like receptor-mediated CCAAT/enhancer-binding protein β activation and protects from inflammatory disease
Jingran Zhou et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
CYLD: a tumor suppressor deubiquitinase regulating NF-kappa B activation and diverse biological processes
S-C Sun
CELL DEATH AND DIFFERENTIATION (2010)
c-IAP1 and UbcH5 promote K11-linked polyubiquitination of RIP1 in TNF signalling
Jasmin N. Dynek et al.
EMBO JOURNAL (2010)
The Ubiquitin Modifying Enzyme A20 Restricts B Cell Survival and Prevents Autoimmunity
Rita M. Tavares et al.
IMMUNITY (2010)
Enterocyte-specific A20 deficiency sensitizes to tumor necrosis factor-induced toxicity and experimental colitis
Lars Vereecke et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2010)
K11-Linked Polyubiquitination in Cell Cycle Control Revealed by a K11 Linkage-Specific Antibody
Marissa L. Matsumoto et al.
MOLECULAR CELL (2010)
Ubiquitin Binding to A20 ZnF4 Is Required for Modulation of NF-κB Signaling
Ivan Bosanac et al.
MOLECULAR CELL (2010)
A20 is targeted by promoter methylation, deletion and inactivating mutation in MALT lymphoma
E. Chanudet et al.
LEUKEMIA (2010)
Multiple modification and protein interaction signals drive the Ring finger protein 11 (RNF11) E3 ligase to the endosomal compartment
E. Santonico et al.
ONCOGENE (2010)
Inhibition of NF-κB Signaling by A20 Through Disruption of Ubiquitin Enzyme Complexes
Noula Shembade et al.
SCIENCE (2010)
Targeting A20 Decreases Glioma Stem Cell Survival and Tumor Growth
Anita B. Hjelmeland et al.
PLOS BIOLOGY (2010)
Regulation and Cellular Roles of Ubiquitin-Specific Deubiquitinating Enzymes
Francisca E. Reyes-Turcu et al.
ANNUAL REVIEW OF BIOCHEMISTRY (2009)
The zinc finger protein A20 targets TRAF2 to the lysosomes for degradation
Lianyun Li et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2009)
TNFAIP3/A20 functions as a novel tumor suppressor gene in several subtypes of non-Hodgkin lymphomas
Keiichiro Honma et al.
BLOOD (2009)
The ubiquitin-editing enzyme A20 requires RNF11 to downregulate NF-κB signalling
Noula Shembade et al.
EMBO JOURNAL (2009)
Molecular discrimination of structurally equivalent Lys 63-linked and linear polyubiquitin chains
David Komander et al.
EMBO REPORTS (2009)
Linear polyubiquitination: a new regulator of NF-κB activation
Kazuhiro Iwai et al.
EMBO REPORTS (2009)
A20 is overexpressed in glioma cells and may serve as a potential therapeutic target
Qingdong Guo et al.
EXPERT OPINION ON THERAPEUTIC TARGETS (2009)
TNFAIP3 (A20) is a tumor suppressor gene in Hodgkin lymphoma and primary mediastinal B cell lymphoma
Roland Schmitz et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2009)
Inhibition of MALT1 protease activity is selectively toxic for activated B cell-like diffuse large B cell lymphoma cells
Uta Ferch et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2009)
A20 Negatively Regulates T Cell Receptor Signaling to NF-κB by Cleaving Malt1 Ubiquitin Chains
Michael Duewel et al.
JOURNAL OF IMMUNOLOGY (2009)
ABIN-1 is a ubiquitin sensor that restricts cell death and sustains embryonic development
Shigeru Oshima et al.
NATURE (2009)
Mutations of multiple genes cause deregulation of NF-κB in diffuse large B-cell lymphoma
Mara Compagno et al.
NATURE (2009)
Frequent inactivation of A20 in B-cell lymphomas
Motohiro Kato et al.
NATURE (2009)
Involvement of linear polyubiquitylation of NEMO in NF-κB activation
Fuminori Tokunaga et al.
NATURE CELL BIOLOGY (2009)
Breaking the chains: structure and function of the deubiquitinases
David Komander et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2009)
Involvement of Ymer in suppression of NF-κB activation by regulated interaction with lysine-63-linked polyubiquitin chain
Miyuki Bohgaki et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2008)
The HECT family of E3 ubiquitin ligases: Multiple players in cancer development
Francesca Bernassola et al.
CANCER CELL (2008)
Shared principles in NF-κB signaling
Matthew S. Hayden et al.
CELL (2008)
Ubiquitin-mediated regulation of TNFR1 signaling
Ingrid E. Wertz et al.
CYTOKINE & GROWTH FACTOR REVIEWS (2008)
Inflammatory cardiac valvulitis in TAX1BP1-deficient mice through selective NF-κB activation
Hidekatsu Iha et al.
EMBO JOURNAL (2008)
Atypical ubiquitin chains: new molecular signals - 'Protein modifications: Beyond the usual suspects' review series
Fumiyo Ikeda et al.
EMBO REPORTS (2008)
The ubiquitin-editing enzyme A20 restricts nucleotide-binding oligomerization domain containing 2-triggered signals
Osamu Hitotsumatsu et al.
IMMUNITY (2008)
Homeostatic MyD88-dependent signals cause lethal inflammation in the absence of A20
Emre E. Turer et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2008)
Signature biomarkers in Crohn's disease: toward a molecular classification
R. Arsenescu et al.
MUCOSAL IMMUNOLOGY (2008)
Common variants at CD40 and other loci confer risk of rheumatoid arthritis
Soumya Raychaudhuri et al.
NATURE GENETICS (2008)
The E3 ligase Itch negatively regulates inflammatory signaling pathways by controlling the function of the ubiquitin-editing enzyme A20
Noula Shembade et al.
NATURE IMMUNOLOGY (2008)
T cell antigen receptor stimulation induces MALT1 paracaspase-mediated cleavage of the NF-κB inhibitor A20
Beatrice Coornaert et al.
NATURE IMMUNOLOGY (2008)
A20 is an antigen presentation attenuator, and its inhibition overcomes regulatory T cell-mediated suppression
Xiao-Tong Song et al.
NATURE MEDICINE (2008)
Ubiquitin binding mediates the NF-kappa B inhibitory potential of ABIN proteins
S. Wagner et al.
ONCOGENE (2008)
AIP4/Itch Regulates Notch Receptor Degradation in the Absence of Ligand
Patricia Chastagner et al.
PLOS ONE (2008)
A critical role of RICK/RIP2 polyubiquitination in Nod-induced NF-κB activation
Mizuho Hasegawa et al.
EMBO JOURNAL (2008)
Deubiquitylation and regulation of the immune response
Shao-Cong Sun
NATURE REVIEWS IMMUNOLOGY (2008)
IκB kinase β phosphorylates the K63 deubiquitinase A20 to cause feedback inhibition of the NF-κB pathway
Jessica E. Hutti et al.
MOLECULAR AND CELLULAR BIOLOGY (2007)
Essential role for TAX1BP1 in the termination of TNF-α-, IL-1- and LPS-mediated NF-κB and JNK signaling
Noula Shembade et al.
EMBO JOURNAL (2007)
A20/TNFAIP3, a new estrogen-regulated gene that confers tamoxifen resistance in breast cancer cells
J. A. Vendrell et al.
ONCOGENE (2007)
Ubiquitination of RIP1 regulates an NF-κB independent cell-death switch in TNF signaling
Marie Anne O'Donnell et al.
CURRENT BIOLOGY (2007)
ABIN-1 binds to NEMO/IKKγ and co-operates with A20 in inhibiting NF-κB
Claudio Mauro et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Activation of IKK by TNFα requires site-specific ubiquitination of RIP1 and polyubiquitin binding by NEMO
CK Ea et al.
MOLECULAR CELL (2006)
A genomic and functional inventory of deubiquitinating enzymes
SMB Nijman et al.
CELL (2005)
RNF11 is a multifunctional modulator of growth factor receptor signalling and transcriptional regulation
P Azmi et al.
EUROPEAN JOURNAL OF CANCER (2005)
Enhanced NF-κB activation and cellular function in macrophages lacking IκB kinase 1 (IKK1)
QT Li et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
IKKα limits macrophage NF-κB activation and contributes to the resolution of inflammation
T Lawrence et al.
NATURE (2005)
Zinc-finger protein A20, a regulator of inflammation and cell survival, has de-ubiquitinating activity
PC Evans et al.
BIOCHEMICAL JOURNAL (2004)
TAB2 and TAB3 activate the NF-κB pathway through binding to polyubiquitin chains
A Kanayama et al.
MOLECULAR CELL (2004)
De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-κB signalling
IE Wertz et al.
NATURE (2004)
JAMM: A metalloprotease-like zinc site in the proteasome and signalosome
XI Ambroggio et al.
PLOS BIOLOGY (2004)
Functional proteomics mapping of a human signaling pathway
F Colland et al.
GENOME RESEARCH (2004)
The ubiquitin-modifying enzyme A20 is required for termination of Toll-like receptor responses
DL Boone et al.
NATURE IMMUNOLOGY (2004)
The RING-H2 protein RNF11 is overexpressed in breast cancer and is a target of Smurf2 E3 ligase
V Subramaniam et al.
BRITISH JOURNAL OF CANCER (2003)
The RING-H2 protein RNF11 is differentially expressed in breast tumours and interacts with HECT-type E3 ligases
R Kitching et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2003)
Toll-like receptor signaling
S Akira
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Structure-function analysis of the A20-binding inhibitor of NF-κB activation, ABIN-1
K Heyninck et al.
FEBS LETTERS (2003)
Interleukin-1 (IL-1) receptor-associated kinase-dependent IL-1-induced signaling complexes phosphorylate TAK1 and TAB2 at the plasma membrane and activate TAK1 in the cytosol
ZF Jiang et al.
MOLECULAR AND CELLULAR BIOLOGY (2002)
TAK1 is a ubiquitin-dependent kinase of MKK and IKK
C Wang et al.
NATURE (2001)
Functional redundancy of the zinc fingers of A20 for inhibition of NF-κB activation and protein-protein interactions
M Klinkenberg et al.
FEBS LETTERS (2001)
Activation of the IκB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain
L Deng et al.
CELL (2000)
Failure to regulate TNF-induced NF-κB and cell death responses in A20-deficient mice
EG Lee et al.
SCIENCE (2000)
T6BP, a TRAF6-interacting protein involved in IL-1 signaling
L Ling et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)
Share Paper
