Journal
CELLULAR & MOLECULAR IMMUNOLOGY
Volume 9, Issue 5, Pages 386-389Publisher
CHIN SOCIETY IMMUNOLOGY
DOI: 10.1038/cmi.2012.31
Keywords
allergy; asthma; IgE; follicular helper T cells
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T follicular helper (Tfh) cells were discovered just over a decade ago as germinal centre T cells that help B cells make antibodies. Included in this role is affinity maturation and isotype switching. It is here that their functions become less clear. Tfh cells principally produce IL-21 which inhibits class switching to IgE. Recent studies have questioned whether the germinal centre is the main site of IgE class switching or IgE affinity maturation. In this review, I will examine the evidence that these cells are responsible for regulating IgE class switching and the relationship between Tfh cells and T helper 2 (Th2) effector cells. Cellular & Molecular Immunology (2012) 9, 386-389; doi:10.1038/cmi.2012.31; published online 20 August 2012
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