Journal
CELLULAR & MOLECULAR IMMUNOLOGY
Volume 9, Issue 1, Pages 11-19Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/cmi.2011.47
Keywords
bone marrow; immunity; memory T cell; regulatory T cell; tumor
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Funding
- NIH/NCI [R01CA133620]
- NIH through the University of Michigan's Cancer Center [5 P30 CA46592]
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Bone marrow is thought to be a primary hematopoietic organ. However, accumulated evidences demonstrate that active function and trafficking of immune cells, including regulatory T cells, conventional T cells, B cells, dendritic cells, natural killer T (NKT) cells, neutrophils, myeloid-derived suppressor cells and mesenchymal stem cells, are observed in the bone marrow. Furthermore, bone marrow is a predetermined metastatic location for multiple human tumors. In this review, we discuss the immune network in the bone marrow. We suggest that bone marrow is an immune regulatory organ capable of fine tuning immunity and may be a potential therapeutic target for immunotherapy and immune vaccination. Cellular & Molecular Immunology (2012) 9, 11-19; doi:10.1038/cmi.2011.47; published online 24 October 2011
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