Journal
CELLULAR & MOLECULAR IMMUNOLOGY
Volume 8, Issue 2, Pages 103-109Publisher
CHIN SOCIETY IMMUNOLOGY
DOI: 10.1038/cmi.2010.65
Keywords
antibody; celiac disease; diagnostics; pathogenesis
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Funding
- Academy of Finland
- Sigrid Juselius Fundation
- Pediatric Research Foundation
- Tampere University Hospital
- European Commission IAPP frant TRANSCOM [PIA-GA-2010-251506]
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Celiac disease is a multisystemic dietary, gluten-induced autoimmune disorder characterized by the presence of transglutaminase (TG) 2 serum autoantibodies. Distinct autoantibodies targeting members of the TG family (TG2, TG3 and TG6) are found deposited in small-bowel mucosa and in extraintestinal tissues affected by the disease. Serum autoantibodies against other self-antigens also emerge in untreated celiac disease patients. Although villous atrophy and crypt hyperplasia in small-bowel biopsy samples are still the gold standards in diagnostics, celiac disease-specific antibodies are widely used as diagnostic aids. Gluten-induced small-bowel mucosal T-cell response is the cornerstone in the pathogenesis of the disorder, but humoral immunity may also play a central role. This review article is focused on the autoantibodies that occur in the context of celiac disease. The article summarizes the diagnostic utility of different celiac-related antibodies and discusses their roles in the pathogenesis of the disease. Cellular & Molecular Immunology (2011) 8, 103-109; doi:10.1038/cmi.2010.65; published online 31 January 2011
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