Journal
CELLULAR & MOLECULAR IMMUNOLOGY
Volume 7, Issue 5, Pages 328-333Publisher
CHIN SOCIETY IMMUNOLOGY
DOI: 10.1038/cmi.2010.27
Keywords
inflammation; interleukin-17; signaling
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Funding
- American Asthma Foundation
- Multiple Sclerosis Society
- National Natural Science Foundation of China [30930084, 30871298, 30928025]
- 973 Program [2010CB529705]
- Chinese Academy of Sciences [KSCX2-YW-R-146, KSCX1-YW-22]
- Science and Technology Commission of Shanghai Municipality [08PJ14110]
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Interleukin (IL)-17, the signature cytokine secreted by T helper (Th) 17 cells, plays important roles in host defense against extracellular bacterial infection and fungal infection and contributes to the pathogenesis of various autoimmune inflammatory diseases. Here we review the recent advances in IL-17-mediated functions with emphasis on the studies of IL-17-mediated signal transduction, providing perspective on potential drug targets for the treatment of autoimmune inflammatory diseases. Cellular & Molecular Immunology (2010) 7, 328-333; doi:10.1038/cmi.2010.27; published online 31 May 2010
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