Journal
CELLULAR & MOLECULAR IMMUNOLOGY
Volume 7, Issue 3, Pages 190-197Publisher
CHIN SOCIETY IMMUNOLOGY
DOI: 10.1038/cmi.2010.24
Keywords
autoimmunity; Bcl6; costimulation; IL-21; T follicular helper (Tfh) cells
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Funding
- National Institutes of Health
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI083761] Funding Source: NIH RePORTER
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A fundamental function of T helper (Th) cells is to regulate B-cell proliferation and immunoglobulin class switching, especially in the germinal centers. Th1 and Th2 lineages of CD4(+) T cells have long been considered to play an essential role in helping B cells by promoting the production immunoglobulin G2a (IgG2a) and IgG1/IgE, respectively. Recently, it has become clear that a subset CD4(+) T cells, named T follicular helper (Tfh) cells, is critical to B-cell response induction. In this review, we summarize the latest advances in our understanding of the regulation of Tfh cell differentiation, the relationship of Tfh cells to other CD4(+) T-cell lineages, and the role of Tfh cells in health and disease. Cellular & Molecular Immunology (2010) 7, 190-197; doi:10.1038/cmi.2010.24; published online 12 April 2010
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