Journal
JOURNAL OF HUMAN GENETICS
Volume 48, Issue 12, Pages 668-671Publisher
SPRINGER-VERLAG TOKYO
DOI: 10.1007/s10038-003-0088-1
Keywords
zinc finger protein; breast cancer; tumor suppressor; 16q24.3; polymorphism
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Loss of heterozygosity (LOH) involving chromosome 16q23.4 occurs frequently in breast tumors, which suggests that this region may contain a tumor suppressor gene. Since ZFP276 is located in this region, we have therefore cloned and performed mutation analysis of its coding region in 70 breast tumors. One silent polymorphism and two alterations predicted to result in amino acid changes were detected. Absence of the wild-type allele in tumors carrying the E530D variant suggests a possible role for this change in tumorigenesis.
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