Journal
CURRENT OPINION IN NEUROBIOLOGY
Volume 13, Issue 6, Pages 685-690Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.conb.2003.10.013
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The analysis of the neural mechanisms responsible for reward-related learning has benefited from recent studies of the effects of dopamine on synaptic plasticity. Dopamine-dependent synaptic plasticity may lead to strengthening of selected inputs on the basis of an activity-dependent conjunction of sensory afferent activity, motor output activity, and temporally related firing of dopamine cells. Such plasticity may provide a link between the reward-related firing of dopamine cells and the acquisition of changes in striatal cell activity during learning. This learning mechanism may play a special role in the translation of reward signals into context-dependent response probability or directional bias in movement responses.
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