Journal
CELLULAR & MOLECULAR IMMUNOLOGY
Volume 7, Issue 2, Pages 152-156Publisher
CHIN SOCIETY IMMUNOLOGY
DOI: 10.1038/cmi.2009.118
Keywords
Real-time RT-PCR; SLE; Tim-1; Tim-4; TNF-alpha
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Funding
- National Natural Science Foundation of China [30872298]
- Independent Innovation Foundation of Shandong University [2009TS115]
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Systemic lupus erythematosus(SLE) is a prototypic autoimmune disease. Innate and adaptive immunity cooperatively contribute to the development of SLE. Antigen-presenting cells (APCs) have been suggested to link innate and adaptive immunity. T-cell immunoglobulin- and mucin-domain-containing molecule-4 (Tim-4; also known as Timd4), expressed primarily on the surface of APCs, is a member of the TIM family, a recently described group of molecules that have received much attention as potential regulators of the immune system. In this study, we used quantitative real-time reverse transcription-polymerase chain reaction to examine the mRNA expression of Tim-4 in peripheral blood mononuclear cells (PBMCs) from SLE patients and further analyzed the correlation between the expression of Tim-4 and Tim-1 (a potential ligand for Tim-4) in PBMCs and serum tumor necrosis factor (TNF)-alpha levels. The results showed that Tim-4 mRNA expression in PBMCs was significantly higher in SLE patients than in healthy controls, especially those patients in the active phase of disease. Moreover, Tim-4 mRNA levels were closely correlated with Tim-1 mRNA levels in PBMCs and with serum TNF-alpha levels in SLE patients but not in the control group. Taken together, these results demonstrate that Tim-4 may be involved in the pathogenesis of SLE. Cellular & Molecular Immunology (2010) 7, 152-156; doi:10.1038/cmi.2009.118; published online 8 February 2010
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