Reagentless detection of DNA sequences on chemically modified electrodes

Microarray analysis requires complex optical instruments and numerous reagents. Several new electrochemical methods for creating sequence-selective microlocations are emerging; such approaches potentially facilitate electrochemical (electronic) readouts of microarrays. These developments parallel the migration of glucose sensing in diabetes monitoring from optical to electrochemical methods. Recent work provides a strategy that minimizes the use of added reagents and potentially produces a reusable sensor that can be applied to continuous monitoring applications.