Journal
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
Volume 29, Issue 2, Pages 241-246Publisher
MARCEL DEKKER INC
DOI: 10.1081/DDC-120016732
Keywords
pentoxifylline; xanthan gum; controlled release; matrix tablets
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Pentoxifylline-controlled release tablets were prepared using xanthan gum. The effects of polymer concentration, rotation speed, ionic strength, and pH of the dissolution medium on the release of the water-soluble pentoxifylline were studied. The release rate decreased with increasing polymer concentration in the tablet, which was reflected in the increase in the mean dissolution time. A higher rotation speed and increased ionic strength of the dissolution medium resulted in a higher rate of drug release of xanthan-based tablets. A higher release rate of pentoxifylline was also observed using acidic dissolution medium.
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