Journal
MOLECULAR PSYCHIATRY
Volume 8, Issue 9, Pages 811-820Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.mp.4001337
Keywords
myelin-associated glycoprotein; 2 ',3 '-cyclic nucleotide 3 '-phosphodiesterase; frontal lobe; T2 relaxation; schizophrenia; oligodendrocyte
Funding
- NATIONAL INSTITUTE OF MENTAL HEALTH [R01MH040210, R01MH060877] Funding Source: NIH RePORTER
- NIMH NIH HHS [MH60877, MH40210] Funding Source: Medline
- PHS HHS [MT46745] Funding Source: Medline
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Schizophrenia unfolds during the late period of brain maturation, while myelination is still continuing. In the present study, we used MRI and T2 relaxation analysis to measure the myelin water fraction in schizophrenia. In schizophrenia ( n = 30) compared with healthy subjects ( n = 27), overall white matter showed 12% lower myelin water fraction ( P = 0.031), with the most prominent effects on the left genu of the corpus callosum (36% lower, P = 0.002). The left anterior genu was affected in both first-episode (P = 0.035) and chronic patients (P = 0.011). In healthy subjects, myelin water fraction in total white matter and in frontal white matter increased with age, and with years of education, indicating ongoing maturation. In patients with schizophrenia, neither relation was statistically significant. Post-mortem studies of anterior frontal cortex demonstrated less immunoreactivity of two oligodendrocyte-associated proteins in schizophrenia (2',3'-cyclic nucleotide 3'-phosphodiesterase by 33%, P = 0.05; myelin-associated glycoprotein by 27%, P = 0.14). Impaired myelination in schizophrenia could contribute to abnormalities of neural connectivity and persistent functional impairment in the illness.
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