Journal
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Volume 38, Issue 1, Pages 101-107Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/S0223-5234(02)01420-4
Keywords
2-phenylnaphthalene-type; 11H-indolo[3.2-c]quinoline derivatives; antitumor activity
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Funding
- NATIONAL CANCER INSTITUTE [P01CA018856] Funding Source: NIH RePORTER
- NCI NIH HHS [CA 18856] Funding Source: Medline
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Designed as a new group of planar molecule containing the proposed 2-phenylnaphthalene-type structure, a number of 11H-indolo[3.2-c]quinoline derivatives were synthesized and evaluated biologically. Several compounds were found to possess cytotoxic activity against the growth of human promyclocytic leukemia cells (HL-60), against the small cell lung cancer (SCLC), and showed good response in the National Cancer Institute preclinical antitumor drug discovery 60-cell line panel. (C) 2002 Editions scientifiques et medicales Elsevier SAS. All rights reserved.
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