Journal
CELLS TISSUES ORGANS
Volume 189, Issue 1-4, Pages 153-157Publisher
KARGER
DOI: 10.1159/000151377
Keywords
Biglycan; WISP-1/CCN4; WISP-1va; Osteogenesis; Proliferation
Funding
- Intramural NIH HHS [Z01 DE000379-24] Funding Source: Medline
- NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH [ZIADE000074, ZIADE000379] Funding Source: NIH RePORTER
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Biglycan ( BGN) and WISP-1 are 2 extracellular matrix proteins that bind to each other and colocalize in mineralizing tissue. Here we show that WISP-1 abrogates the repression of proliferation in bone marrow stromal cells induced by BGN. We also demonstrate that WISP-1 and its variant WISP-1va can alleviate the repressed osteogenic differentiation caused by the absence of BGN. These preliminary data suggest that WISP-1 and BGN may functionally interact and control each other's activity, thus regulating the differentiation and proliferation of osteogenic cells. Copyright (C) 2008 S. Karger AG, Basel
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