Journal
EUROPEAN NEUROLOGY
Volume 50, Issue 2, Pages 64-68Publisher
KARGER
DOI: 10.1159/000072500
Keywords
neurogenetics; Parkinson's disease; HLA; neurodegenerative disorder; linkage disequilibrium
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Idiopathic Parkinson's disease (IPD) is a neurodegenerative disorder of unknown aetiology. Several antigens have been associated with IPD using serological methods. We systematically analysed HLA class I and 11 alleles in 45 German Caucasian IPD patients using sequence-specific oligonucleotides and sequence-specific primer technology. Applying Bonferroni adjusted p values, we demonstrate a statistically significant increase of the DQB1*06 allele (p = 0.002) in IPD which may indicate an association between IPD and the immune system. Alternatively, HLA alleles might be in linkage disequilibrium with genes located next to the HLA locus. Copyright (C) 2003 S. Karger AG, Basel.
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