Related references
Note: Only part of the references are listed.Genetics of Parkinson's Disease
Christine Klein et al.
COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2012)
Culture media for the differentiation of mesenchymal stromal cells
Corina Vater et al.
ACTA BIOMATERIALIA (2011)
VEGF-expressing human umbilical cord mesenchymal stem cells, an improved therapy strategy for Parkinson's disease
N. Xiong et al.
GENE THERAPY (2011)
A pilot trial of the microtubule-interacting peptide (NAP) in mice overexpressing alpha-synuclein shows improvement in motor function and reduction of alpha-synuclein inclusions
Sheila M. Fleming et al.
MOLECULAR AND CELLULAR NEUROSCIENCE (2011)
Cell Transplantation and Gene Therapy in Parkinson's Disease
Dustin R. Wakeman et al.
MOUNT SINAI JOURNAL OF MEDICINE (2011)
Cognitive outcome and reliable change indices two years following bilateral subthalamic nucleus deep brain stimulation
Amy E. Williams et al.
PARKINSONISM & RELATED DISORDERS (2011)
Glucocerebrosidase mutations in diffuse Lewy body disease
Kenya Nishioka et al.
PARKINSONISM & RELATED DISORDERS (2011)
Lewy body pathology in fetal grafts
Yaping Chu et al.
YEAR IN NEUROLOGY 2 (2010)
Inhibition of mitochondrial fusion by α-synuclein is rescued by PINK1, Parkin and DJ-1
Frits Kamp et al.
EMBO JOURNAL (2010)
Parkinson's disease-related LRRK2 G2019S mutation results from independent mutational events in humans
Suzanne Lesage et al.
HUMAN MOLECULAR GENETICS (2010)
Synphilin-1 attenuates neuronal degeneration in the A53T alpha-synuclein transgenic mouse model
Wanli W. Smith et al.
HUMAN MOLECULAR GENETICS (2010)
Phosphorylation of Synucleins by Members of the Polo-like Kinase Family
Martial K. Mbefo et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Phosphorylated α-Synuclein at Ser-129 Is Targeted to the Proteasome Pathway in a Ubiquitin-independent Manner
Youhei Machiya et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Human Umbilical Cord Blood Mononuclear Cell Transplantation in Rats with Intrinsic Sphincter Deficiency
Joa-Jin Lim et al.
JOURNAL OF KOREAN MEDICAL SCIENCE (2010)
Direct conversion of fibroblasts to functional neurons by defined factors
Thomas Vierbuchen et al.
NATURE (2010)
Phenotypic spectrum of patients with PLA2G6 mutation and PARK14-linked parkinsonism
H. Yoshino et al.
NEUROLOGY (2010)
Increased Expression of α-Synuclein Reduces Neurotransmitter Release by Inhibiting Synaptic Vesicle Reclustering after Endocytosis
Venu M. Nemani et al.
NEURON (2010)
DIFFERENTIATION OF NON-MESENCEPHALIC NEURAL STEM CELLS TOWARDS DOPAMINERGIC NEURONS
R. Rossler et al.
NEUROSCIENCE (2010)
Novel GIGYF2 gene variants in patients with Parkinson's disease in Chinese population
Lei Wang et al.
NEUROSCIENCE LETTERS (2010)
LRRK2 G2019S mutation in Parkinson's disease: A neuropsychological and neuropsychiatric study in a large Algerian cohort
Soreya Belarbi et al.
PARKINSONISM & RELATED DISORDERS (2010)
Ubiquitin vinyl methyl ester binding orients the misaligned active site of the ubiquitin hydrolase UCHL1 into productive conformation
David A. Boudreaux et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
alpha-Synuclein Gene Rearrangements in Dominantly Inherited Parkinsonism Frequency, Phenotype, and Mechanisms
Pablo Ibanez et al.
ARCHIVES OF NEUROLOGY (2009)
Lrrk2 phosphorylates alpha synuclein at serine 129: Parkinson disease implications
Hong Qing et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2009)
Metal binding to alpha-synuclein peptides and its contribution to toxicity
David R. Brown
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2009)
Parkinson's Disease Patient-Derived Induced Pluripotent Stem Cells Free of Viral Reprogramming Factors
Frank Soldner et al.
CELL (2009)
Increased alpha-synuclein aggregation following limited cleavage by certain matrix metalloproteinases
Johannes Levin et al.
EXPERIMENTAL NEUROLOGY (2009)
Polo-like Kinase 2 (PLK2) Phosphorylates α-Synuclein at Serine 129 in Central Nervous System
Kelly J. Inglis et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Effects of UCH-L1 on α-synuclein over-expression mouse model of Parkinson's disease
Toru Yasuda et al.
JOURNAL OF NEUROCHEMISTRY (2009)
Initial clinical manifestations of Parkinson's disease: features and pathophysiological mechanisms
Maria C. Rodriguez-Oroz et al.
LANCET NEUROLOGY (2009)
Induced pluripotent stem cells from a spinal muscular atrophy patient
Allison D. Ebert et al.
NATURE (2009)
α-Synuclein is part of a diverse and highly conserved interaction network that includes PARK9 and manganese toxicity
Aaron D. Gitler et al.
NATURE GENETICS (2009)
Review: Deep brain stimulation in Parkinson’s disease
S.J. Groiss et al.
Therapeutic Advances in Neurological Disorders (2009)
Mutations in the GIGYF2 (TNRC15) gene at the PARK11 locus in familial Parkinson disease
Corinne Lautier et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2008)
Genome-wide linkage analysis of a Parkinsonian-pyramidal syndrome pedigree by 500 KSNP arrays
Seyedmehdi Shojaee et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2008)
Impairment of microtubule system increases α-synuclein aggregation and toxicity
Myunghye Kim et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2008)
Phosphorylation of 4E-BP by LRRK2 affects the maintenance of dopaminergic neurons in Drosophila
Yuzuru Imai et al.
EMBO JOURNAL (2008)
Mitochondrial translocation of α-synuclein is promoted by intracellular acidification
Nelson B. Cole et al.
EXPERIMENTAL CELL RESEARCH (2008)
Mitochondrial import and accumulation of α-synuclein impair complex I in human dopaminergic neuronal cultures and Parkinson disease brain
Latha Devi et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Biochemical aspects of the neuroprotective mechanism of PTEN-induced kinase-1 (PINK1)
Ryan D. Mills et al.
JOURNAL OF NEUROCHEMISTRY (2008)
Mesenchymal stem cells therapy exerts neuroprotection in a progressive animal model of Parkinson's disease
Hyun Jung Park et al.
JOURNAL OF NEUROCHEMISTRY (2008)
Specificity and regulation of casein kinase-mediated phosphorylation of α-synuclein
Elisa A. Waxman et al.
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2008)
Deep brain stimulation for Parkinson's disease: Prevalence of adverse events and need for standardized reporting
Aleksandar Videnovic et al.
MOVEMENT DISORDERS (2008)
Lewy body-like pathology in long-term embryonic nigral transplants in Parkinson's disease
Jeffrey H. Kordower et al.
NATURE MEDICINE (2008)
Neurally induced umbilical cord blood cells modestly repair injured spinal cords
Sung-Rae Cho et al.
NEUROREPORT (2008)
The PINK1/Parkin pathway regulates mitochondrial morphology
Angela C. Poole et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Induced pluripotent stem cells generated from patients with ALS can be differentiated into motor neurons
John T. Dimos et al.
SCIENCE (2008)
Induced pluripotent stem cell lines derived from human somatic cells
Junying Yu et al.
SCIENCE (2007)
Parkinson's disease
Bobby Thomas et al.
HUMAN MOLECULAR GENETICS (2007)
Interactions between metals and α-synuclein -: function or artefact?
David R. Brown
FEBS JOURNAL (2007)
Sirtuin 2 inhibitors rescue α-synuclein-mediated toxicity in models of Parkinson's disease
Tiago Fleming Outeiro et al.
SCIENCE (2007)
PINK1 protects against oxidative stress by phosphorylating mitochondrial chaperone TRAP1
Julia W. Pridgeon et al.
PLOS BIOLOGY (2007)
Deciphering the role of heterozygous mutations in genes associated with parkinsonism
Christine Klein et al.
LANCET NEUROLOGY (2007)
ATP13A2 missense mutations in juvenile parkinsonism and young onset Parkinson disease
A. Di Fonzo et al.
NEUROLOGY (2007)
Aggregated α-synuclein mediates dopaminergic neurotoxicity in vivo
Magali Periquet et al.
JOURNAL OF NEUROSCIENCE (2007)
Phenotypic variation in a large Swedish pedigree due to SNCA duplication and triplication
J. Fuchs et al.
NEUROLOGY (2007)
More frequent Lewy bodies but less frequent, Alzheimer-type lesions in multiple system atrophy as compared to age-matched control brains
Kurt A. Jellinger
ACTA NEUROPATHOLOGICA (2007)
Impairment of microtubule-dependent trafficking by overexpression of α-synuclein
He-Jin Lee et al.
EUROPEAN JOURNAL OF NEUROSCIENCE (2006)
Mutations in DJ-1 are rare in familial Parkinson disease
Nathan Pankratz et al.
NEUROSCIENCE LETTERS (2006)
Functional engraftment of human ES cell-derived dopaminergic neurons enriched by coculture with telomerase-immortalized midbrain astrocytes
Neeta S. Roy et al.
NATURE MEDICINE (2006)
Neural differentiation of human mesenchymal stem cells:: evidence for expression of neural markers and eag K+ channel types
Katia Mareschi et al.
EXPERIMENTAL HEMATOLOGY (2006)
Induction of dopaminergic neurons from growth factor expanded neural stem/progenitor cell cultures derived from human first trimester forebrain
Nicolaj S. Christophersen et al.
BRAIN RESEARCH BULLETIN (2006)
α-synuclein acts in the nucleus to inhibit histone acetylation and promote neurotoxicity
Eirene Kontopoulos et al.
HUMAN MOLECULAR GENETICS (2006)
Phosphorylation of Ser-129 is the dominant pathological modification of α-synuclein in familial and sporadic Lewy body disease
John P. Anderson et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Hereditary parkinsonism with dementia is caused by mutations in ATP13A2, encoding a lysosomal type 5 P-type ATPase
Alfredo Ramirez et al.
NATURE GENETICS (2006)
α-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models
Antony A. Cooper et al.
SCIENCE (2006)
PLA2G6, encoding a phospholipase A2, is mutated in neurodegenerative disorders with high brain iron
Neil V. Morgan et al.
NATURE GENETICS (2006)
Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin
Jeehye Park et al.
NATURE (2006)
Stable expression of a neuronal dopaminergic progenitor phenotype in cell lines derived from human amniotic fluid cells
David McLaughlin et al.
JOURNAL OF NEUROSCIENCE RESEARCH (2006)
High levels of mitochondrial DNA deletions in substantia nigra neurons in aging and Parkinson disease
A Bender et al.
NATURE GENETICS (2006)
Mitochondrial DNA deletions are abundant and cause functional impairment in aged human substantia nigra neurons
Y Kraytsberg et al.
NATURE GENETICS (2006)
LRRK2 expression linked to dopamine-innervated areas
D Galter et al.
ANNALS OF NEUROLOGY (2006)
Increased survival and migration of engrafted mesenchymal bone marrow stem cells in 6-hydroxydopamine-lesioned rodents
MA Hellmann et al.
NEUROSCIENCE LETTERS (2006)
Clonal amniotic fluid-derived stem cells express characteristics of both mesenchymal and neural stem cells
MS Tsai et al.
BIOLOGY OF REPRODUCTION (2006)
Mutational analysis of the PINK1 gene in early-onset parkinsonism in Europe and North Africa
P Ibáñez et al.
BRAIN (2006)
Cooperative transcription activation by Nurr1 and Pitx3 induces embryonic stem cell maturation to the midbrain dopamine neuron phenotype
C Martinat et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
LRRK2 G2019S as a cause of Parkinson's disease in North African Arabs
S Lesage et al.
NEW ENGLAND JOURNAL OF MEDICINE (2006)
LRRK2 G2019S as a cause of Parkinson's disease in Ashkenazi Jews
LJ Ozelius et al.
NEW ENGLAND JOURNAL OF MEDICINE (2006)
Epidemiology of Parkinson's disease
Lonneke M. L. de Lau et al.
LANCET NEUROLOGY (2006)
Small interfering RNA targeting the PINK1 induces apoptosis in dopaminergic cells SH-SY5Y
H Deng et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2005)
Transplanted human embryonic germ cell-derived neural stem cells replace neurons and oligodendrocytes in the forebrain of neonatal mice with excitotoxic brain damage
D Mueller et al.
JOURNAL OF NEUROSCIENCE RESEARCH (2005)
Mitochondrial localization of the Parkinson's disease related protein DJ-1: implications for pathogenesis
L Zhang et al.
HUMAN MOLECULAR GENETICS (2005)
Early-onset parkinsonism associated with PINK1 mutations -: Frequency, genotypes, and phenotypes
V Bonifati et al.
NEUROLOGY (2005)
Therapeutic benefit of TH-engineered mesenchymal stem cells for Parkinson's disease
LL Lu et al.
BRAIN RESEARCH PROTOCOLS (2005)
Genetic and genomic studies of Drosophila parkin mutants implicate oxidative stress and innate immune responses in pathogenesis
JC Greene et al.
HUMAN MOLECULAR GENETICS (2005)
A femtomolar acting octapeptide interacts with tubulin and protects astrocytes against zinc intoxication
I Divinski et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Mutations in LRRK2 cause autosomal-dominant Parkinsonism with pleomorphic pathology
A Zimprich et al.
NEURON (2004)
Mutations in the glucocerebrosidase gene and Parkinson's disease in Ashkenazi Jews
J Aharon-Peretz et al.
NEW ENGLAND JOURNAL OF MEDICINE (2004)
Hereditary early-onset Parkinson's disease caused by mutations in PINK1
EM Valente et al.
SCIENCE (2004)
NMR of α-synuclein-polyamine complexes elucidates the mechanism and kinetics of induced aggregation
CO Fernández et al.
EMBO JOURNAL (2004)
Cysteine-106 of DJ-1 is the most sensitive cysteine residue to hydrogen peroxide-mediated oxidation in vivo in human umbilical vein endothelial cells
T Kinumi et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2004)
G209A mutant alpha synuclein expression specifically enhances dopamine induced oxidative damage
M Orth et al.
NEUROCHEMISTRY INTERNATIONAL (2004)
Down regulation of DJ-1 enhances cell death by oxidative stress, ER stress, and proteasome inhibition
T Yokota et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2003)
Molecular pathways of neurodegeneration in Parkinson's disease
TM Dawson et al.
SCIENCE (2003)
Neural subtype specification of fertilization and nuclear transfer embryonic stem cells and application in parkinsonian mice
T Barberi et al.
NATURE BIOTECHNOLOGY (2003)
Highly regionalized distribution of stromal cell-derived factor-1/CXCL12 in adult rat brain:: constitutive expression in cholinergic, dopaminergic and vasopressinergic neurons
G Banisadr et al.
EUROPEAN JOURNAL OF NEUROSCIENCE (2003)
Both apoptosis and necrosis occur early after intracerebral grafting of ventral mesencephalic tissue:: a role for protease activation
M Emgård et al.
JOURNAL OF NEUROCHEMISTRY (2003)
Incidence of Parkinson's disease: Variation by age, gender, and Race/Ethnicity
SK Van Den Eeden et al.
AMERICAN JOURNAL OF EPIDEMIOLOGY (2003)
Identification and functional characterization of a novel R621C mutation in the synphilin-1 gene in Parkinson's disease
FP Marx et al.
HUMAN MOLECULAR GENETICS (2003)
Intravenous administration of human bone marrow stromal cells induces angiogenesis in the ischemic boundary zone after stroke in rats
JL Chen et al.
CIRCULATION RESEARCH (2003)
Mitochondrial pathology and apoptotic muscle degeneration in Drosophila parkin mutants
JC Greene et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Parkin prevents mitochondrial swelling and cytochrome c release in mitochondria-dependent cell death
F Darios et al.
HUMAN MOLECULAR GENETICS (2003)
Mutations in NR4A2 associated with familial Parkinson disease
WD Le et al.
NATURE GENETICS (2003)
Neuroprotection in the rat Parkinson model by intrastriatal GDNF gene transfer using a lentiviral vector
B Georgievska et al.
NEUROREPORT (2002)
Immunocytochemical localization of synphilin-1, an alpha-synuclein-associated protein, in neurodegenerative disorders
K Wakabayashi et al.
ACTA NEUROPATHOLOGICA (2002)
Intracerebral transplantation of bone marrow stromal cells in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease
Y Li et al.
NEUROSCIENCE LETTERS (2001)
Prevalence, incidence, and mortality of PD - A door-to-door survey in Ilan County, Taiwan
RC Chen et al.
NEUROLOGY (2001)
Review of the functional surgical treatment of dystonia
P Krack et al.
EUROPEAN JOURNAL OF NEUROLOGY (2001)
Deep brain stimulation in the treatment of severe dystonia
L Vercueil et al.
JOURNAL OF NEUROLOGY (2001)
Environmental risk factors and Parkinson's disease: A metaanalysis
A Priyadarshi et al.
ENVIRONMENTAL RESEARCH (2001)
DJ-1 is an indicator for endogenous reactive oxygen species elicited by endotoxin
A Mitsumoto et al.
FREE RADICAL RESEARCH (2001)
Organization of the human synphilin-1 gene, a candidate for Parkinson's disease
S Engelender et al.
MAMMALIAN GENOME (2000)
Synucleins are a novel class of substrates for G protein-coupled receptor kinases
AN Pronin et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase
H Shimura et al.
NATURE GENETICS (2000)
Association between early-onset Parkinson's disease and mutations in the parkin gene
CB Lücking et al.
NEW ENGLAND JOURNAL OF MEDICINE (2000)
Improving the survival of grafted dopaminergic neurons:: A review over current approaches
P Brundin et al.
CELL TRANSPLANTATION (2000)
Expression patterns of α-synuclein in human hematopoietic cells and in Drosophila at different developmental stages
EC Shin et al.
MOLECULES AND CELLS (2000)
Dopaminergic loss and inclusion body formation in α-synuclein mice:: Implications for neurodegenerative disorders
E Masliah et al.
SCIENCE (2000)
The hsp90-related protein TRAP1 is a mitochondrial protein with distinct functional properties
SJ Felts et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Vasoactive intestinal peptide (VIP) prevents neurotoxicity in neuronal cultures: relevance to neuroprotection in Parkinson's disease
D Offen et al.
BRAIN RESEARCH (2000)
Constitutive phosphorylation of the Parkinson's disease associated α-synuclein
M Okochi et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system
A Abeliovich et al.
NEURON (2000)