Journal
CELL TRANSPLANTATION
Volume 22, Issue 3, Pages 437-445Publisher
SAGE PUBLICATIONS INC
DOI: 10.3727/096368912X656162
Keywords
Angiogenesis; Angiogenic factor; Human adipose-derived stromal cells (hASCs); Platelet-rich plasma (PRP); Wound healing
Funding
- National Research Foundation of Korea [2010-0020352]
- Korea Health 21 R&D Project, Ministry of Health and Welfare, Republic of Korea [A100443]
- National Research Foundation of Korea [2010-0020352] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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The administration of human adipose-derived stromal cells (hASCs) enhances skin wound healing. However, poor survival of hASCs that are administered to avascular wound regions may limit the therapeutic efficacy of the hASCs. The aim of this study was to determine whether the coadministration of platelet-rich plasma (PRP) and hASCs enhanced the skin wound-healing efficacy of hASCs. Skin regeneration was examined in skin wounds of athymic mice that were either untreated or treated with hASCs, PRP, or both hASCs and PRP. Coadministration of PRP and hASCs resulted in better skin regeneration than hASC administration alone in part by significantly improving the proliferation of administered hASCs by the angiogenic growth factor secretion of the hASCs and surrounding mouse host cells in the wound areas and by promoting neovascularization in the wound beds.
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