Journal
NEUROCHEMISTRY INTERNATIONAL
Volume 42, Issue 1, Pages 67-71Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0197-0186(02)00057-8
Keywords
interferon beta-1a; lymphocytes; multiple sclerosis
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The activation of lymphocytes and monocytes and the concentration of reduction equivalents in serum were studied in a cohort of multiple sclerosis (MS) patients undergoing weekly treatment with 30 mug intramuscular interferon beta-1 a for 2 years. The degree of activation of monocytes and lymphocytes and reactive oxygen species (ROS) production was higher in MS patients than in healthy controls and decreased in the course of interferon beta-1a treatment approaching control values. The concentration of reduced sulfhydryls in the serum of MS patients was lower than in healthy controls and the treatment with interferon beta-1a (IFNbeta-1a) raised the levels approaching the values of healthy controls. (C) 2003 Elsevier Science Ltd. All rights reserved.
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