Journal
ANNALS OF BIOMEDICAL ENGINEERING
Volume 31, Issue 1, Pages 53-64Publisher
BIOMEDICAL ENGINEERING SOC AMER INST PHYSICS
DOI: 10.1114/1.1531635
Keywords
atherosclerosis; particle hemodynamics; hemodynamic wall parameters; monocytes; adhesion; deposition; computational fluid dynamics; near-wall residence time
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Funding
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL057446, R29HL041372, R01HL041372] Funding Source: NIH RePORTER
- NHLBI NIH HHS [HL57446, HL41372] Funding Source: Medline
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Transient-particle-hemodynamic simulations were conducted in a model of the rabbit aorto-celiac junction to investigate mechanisms responsible for localized monocyte attachment and subsequent lesion formation. We hypothesized that the probability for monocyte deposition is related to discrete near-wall particle stasis and/or elevated concentrations, as encapsulated by a new near-wall residence time (NWRT) parameter. A low wall shear stress (WSS) condition accounted for factors such as endothelial cell expression of adhesive molecules as well as a reduced probability of monocyte rolling and detachment. To accurately simulate particle transport, terms for the near-wall drag modification and lift were included. Low WSS and high oscillatory shear index parameters proved ineffective compared to localized in-vivo results of monocyte accumulation and lesion initialization. The NWRT parameter, with a limiting WSS condition, identified the lateral flow divider as most susceptible to monocyte deposition, as observed in vivo. A representative quantitative correlation between monocyte deposition and NWRT occurrence was established (r(2) =0.77 and p < 10(-4)) on a highly focal basis for an averaged data set. Results indicate that cell transport and conditions for hemodyamically induced surface reactivity are necessary components in formulating an effective model for monocyte adhesion in complex three-dimensional vessel configurations. (C) 2003 Biomedical Engineering Society.
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