Journal
JOURNAL OF THE SERBIAN CHEMICAL SOCIETY
Volume 68, Issue 4-5, Pages 291-302Publisher
SERBIAN CHEMICAL SOC
DOI: 10.2298/JSC0305291O
Keywords
mixed tetraoxane; malaria; tuberculosis; cancer; peroxide; steroid
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Mixed tetraoxanes of the 4-phenyl-substituted cyclohexyl-spirotetraoxacyclohexyl-spirocholate series have been prepared and evaluated as possible antimalarials, anti-proliferatives and antimycobacterials. The activity of the (4R or S)-phenyl series against P falciarum D6 and W2 strains was found to be at the level of artemisinin. with two compounds. the acid 4 and the amide 6, exhibiting encouraging anti-TB activity as well. Very promising in vitro results of the said tetraoxanes were obtained against solid tumours and, in some instances. the activity against a selected number of cell lines was higher than that of the antitumor drug paclitaxel.
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