Journal
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
Volume 29, Issue 3, Pages 277-287Publisher
MARCEL DEKKER INC
DOI: 10.1081/DDC-120018201
Keywords
powder flow; Carr indices
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Pharmaceutical excipients may have a great effect on properties affecting tablet production. To determine if formulations containing theophylline anhydrous would have properties allowing them to be easily tableted, functional parameters affecting powder flow were evaluated. The Carr Flowability Indices were used for this evaluation. Formulations to be studied include theophylline anhydrous as the active ingredient, hydrous lactose and dicalcium phosphate dihydrate as diluents, polyvinylpyrrolidone as a binder, and fumed silica as a flow promoter. The effect of each component on powder flow is discussed.
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