Journal
CELL TRANSPLANTATION
Volume 21, Issue 6, Pages 1321-1339Publisher
SAGE PUBLICATIONS INC
DOI: 10.3727/096368911X612530
Keywords
Umbilical cord blood; Islets of Langerhans; Pancreas; Adult stem cells; Mesenchymal stem cells (MSCs)
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We sought to assess the potential of human cord blood-derived mesenchymal stem cells (CB-MSCs) to derive insulin-producing, glucose-responsive cells. We show here that differentiation protocols based on stepwise culture conditions initially described for human embryonic stein cells (hESCs) lead to differentiation of cord blood-derived precursors towards a pancreatic endocrine phenotype, as assessed by marker expression and in vitro glucose-regulated insulin secretion. Transplantation of these cells in immune-deficient animals shows human C-peptide production in response to a glucose challenge. These data suggest that human cord blood may be a promising source for regenerative medicine approaches for the treatment of diabetes mellitus.
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