Journal
CELL TRANSPLANTATION
Volume 20, Issue 1, Pages 99-111Publisher
SAGE PUBLICATIONS INC
DOI: 10.3727/096368910X532846
Keywords
Hippocampal neurogenesis; Physical exercise; Stress; Dendritic plasticity
Funding
- University of Hong Kong Foundation for Educational Development and Research Limited
- University Grants Committee of the Hong Kong Special Administrative Region, China [AoE/B-15/01-II]
Ask authors/readers for more resources
It was considered that neurogenesis only occurred during the embryonic and developmental stage. This view has greatly changed since the discovery of adult neurogenesis in two brain regions: the hippocampus and the olfactory bulb. Recently, it is suggested that altered hippocampal neurogenesis is related to pathophysiology of mood disorders and mechanism of antidepressant treatments. Accumulating knowledge about the effects of physical exercise on brain function suggests a special role of adult hippocampal neurogenesis in cognitive and mental health, even though the functional significance of adult neurogenesis is still debated. The beneficial effects of running correlating with increased adult neurogenesis may provide a hint that newborn neurons may be involved, at least in part, in the counteractive mechanism of physical exercise on stress-related disorders, like depression. The present review provides an overview of recent findings to emphasize the possible involvement of hippocampal neurogenesis in mediating the beneficial effects of physical exercise on counteracting stress.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available