Journal
CELL TRANSPLANTATION
Volume 18, Issue 3, Pages 245-254Publisher
SAGE PUBLICATIONS INC
DOI: 10.3727/096368909788534889
Keywords
Stein cells; Cardiovascular repair; Adipose-derived stem cells; Adipose tissue; APOLLO trial; PRECISE trial
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Over the past decade, cell therapy has emerged as a new approach to reversing myocardial ischemia. Several types of adult stem cells have been studied in both preclinical and clinical conditions for this purpose: bone marrow cells, circulating cells, and myoblasts. Nevertheless, the quest for the ideal anti-ischemic cell is still ongoing. Recently, the existence of a population of stem cells located in adipose tissue (adipose-derived stem cells) has been observed. These are able to differentiate into multiple cell lineages including cardiomyocytic differentiation. In this review we discuss the basic principles of adipose-derived stem cells (types and characteristics, harvesting, and expansion), the initial experimental studies, and the currently ongoing clinical trials.
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