Journal
AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY
Volume 11, Issue 6, Pages 678-682Publisher
AMER PSYCHIATRIC PRESS, INC
DOI: 10.1176/appi.ajgp.11.6.678
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Funding
- NATIONAL INSTITUTE OF MENTAL HEALTH [K07MH001367, P50MH060451, R01MH054846] Funding Source: NIH RePORTER
- NIMH NIH HHS [K07 MH01367, R01 MH54846, P50 MH60451] Funding Source: Medline
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Objective: The authors correlated magnetic resonance imaging (MRI) lesion severity and mortality among depressed elderly patients. Method: They examined the association of mortality and deep white-matter hyperintensity (DWMH), periventricular hyperintensity (PVH), and subcortical gray-matter hyperintensity (SGH) ratings in 259 subjects. Results: DWMH and PVH were significantly associated with mortality initially, and, in final modeling, DWMH remained significant. Conclusion: These findings suggest that there is a relationship between cerebrovascular disease severity and mortality among depressed patients. More studies, with larger sample sizes, comparing depressed patients and control subjects are needed to further elucidate this relationship.
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