Journal
NUCLEAR MEDICINE AND BIOLOGY
Volume 30, Issue 8, Pages 811-817Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/S0969-8051(03)00117-3
Keywords
folate receptor; folate binding protein; tumor targeting; radiopharmaceutical; radionuclide imaging
Funding
- NATIONAL CANCER INSTITUTE [R01CA070845] Funding Source: NIH RePORTER
- NCI NIH HHS [R01-CA70845] Funding Source: Medline
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The cell-membrane folate receptor is a potential molecular target for tumor-selective drug delivery, including radiolabeled folate-chelate conjugates for diagnostic imaging. We review here some background on the folate receptor as tumor-associated molecular target for drug delivery, and briefly survey the literature on tumor-targeting with radiolabeled folate-chelate conjugates. (C) 2003 Elsevier Inc. All rights reserved.
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