Journal
TRENDS IN CELL BIOLOGY
Volume 13, Issue 11, Pages 570-576Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcb.2003.09.002
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Funding
- NATIONAL CENTER FOR RESEARCH RESOURCES [P41RR013186] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R24GM064437] Funding Source: NIH RePORTER
- NCRR NIH HHS [RR 13186] Funding Source: Medline
- NIGMS NIH HHS [GM 64437] Funding Source: Medline
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Cell biological processes are controlled by an interacting set of biochemical and electrophysiological events that are distributed within complex cellular structures. Computational models, comprising quantitative data on the interacting molecular participants in these events, provide a means for applying the scientific method to these complex systems. The Virtual Cell is a computational environment designed for cell biologists, to facilitate the construction of models and the generation of predictive simulations from them. This review summarizes how a Virtual Cell model is assembled and describes the physical principles underlying the calculations that are performed. Applications to problems in nucleocytoplasmic transport and intracellular calcium dynamics will illustrate the power of this paradigm for elucidating cell biology.
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