Journal
CELL STRESS & CHAPERONES
Volume 16, Issue 5, Pages 565-572Publisher
SPRINGER
DOI: 10.1007/s12192-011-0267-5
Keywords
Aspergillus nidulans; pH sensing; pal signaling pathway; HSP
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Funding
- Brazilian funding agency FAPESP
- Brazilian funding agency CNPq
- Brazilian funding agency CAPES
- Brazilian funding agency FAEPA
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Heat shock proteins are molecular chaperones linked to a myriad of physiological functions in both prokaryotes and eukaryotes. In this study, we show that the Aspergillus nidulans hsp30 (ANID_03555.1), hsp70 (ANID_05129.1), and hsp90 (ANID_08269.1) genes are preferentially expressed in an acidic milieu, whose expression is dependent on the palA (+) background under optimal temperature for fungal growth. Heat shock induction of these three hsp genes showed different patterns in response to extracellular pH changes in the palA(+) background. However, their accumulation upon heating for 2 h was almost unaffected by ambient pH changes in the palA (-) background. The PalA protein is a member of a conserved signaling cascade that is involved in the pH-mediated regulation of gene expression. Moreover, we identified several genes whose expression at pH 5.0 is also dependent on the palA (+) background. These results reveal novel aspects of the heat- and pH-sensing networks of A. nidulans.
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