Journal
JOURNAL OF MOLECULAR MEDICINE-JMM
Volume 81, Issue 12, Pages 757-765Publisher
SPRINGER-VERLAG
DOI: 10.1007/s00109-003-0489-9
Keywords
major histocompatibility complex; caspase-independent apoptosis; protein kinase C; MHC-II specific monoclonal antibodies
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Major histocompatibility complex class II (MHC-II) molecules, in addition to their role of presenting antigen to T lymphocytes, can serve as receptors triggering programmed cell death. MHC-II induced cell death affects activated/tumour transformed cells selectively, and it proceeds without the involvement of caspases, the major proteases of classical apoptosis. Caspase-independent programmed cell death can also be triggered, albeit less effectively, via a series of other cell surface molecules. Here, we discuss the major characteristics, physiological significance, and clinical relevance of caspase-independent apoptotic pathways with particular emphasis on the one induced by MHC-II ligation.
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