Journal
CELL STRESS & CHAPERONES
Volume 15, Issue 1, Pages 1-11Publisher
SPRINGER
DOI: 10.1007/s12192-009-0127-8
Keywords
Smooth muscle; Skeletal muscle; Cardiac muscle; HSPB6
Categories
Funding
- National Institute of Health [RO1HL58027, RO1HL70715]
- Veterans Administration
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL058027, R01HL070715] Funding Source: NIH RePORTER
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The small heat shock protein, HSPB6, is a 17-kDa protein that belongs to the small heat shock protein family. HSPB6 was identified in the mid-1990s when it was recognized as a by-product of the purification of HSPB1 and HSPB5. HSPB6 is highly and constitutively expressed in smooth, cardiac, and skeletal muscle and plays a role in muscle function. This review will focus on the physiologic and biochemical properties of HSPB6 in smooth, cardiac, and skeletal muscle; the putative mechanisms of action; and therapeutic implications.
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