Journal
CELL STEM CELL
Volume 23, Issue 4, Pages 572-+Publisher
CELL PRESS
DOI: 10.1016/j.stem.2018.08.002
Keywords
-
Categories
Funding
- Sao Paulo Research Foundation (FAPESP)
- Brazil/Weizmann Institute of Science, Israel [2015/50166-8]
- Dr. Beth Rom-Rymer Stem Cell Research Fund
- Canadian Institutes of Health Research (CIHR)
- International Development Research Centre (IDRC)
- Israel Science Foundation (ISF)
- Azrieli Foundation [2655/16]
- Ernest and Bonnie Beutler Research Program of Excellence in Genomic Medicine
- ISF-NSFC joint research program [2474/16]
- Pertman Fund for Stem Cell Research
- Mashkin Family Foundation
- CAMS Initiative for Innovative Medicine [2016-I2M-1-017]
- CAMS Fundamental Research Funds for Central Research Institutes [2016GH3100001]
Ask authors/readers for more resources
Hematopoietic stem and progenitor cells (HSPCs) tightly couple maintenance of the bone marrow (BM) reservoir, including undifferentiated long-term repopulating hematopoietic stem cells (LT-HSCs), with intensive daily production of mature leukocytes and blood replenishment. We found two daily peaks of BM HSPC activity that are initiated by onset of light and darkness providing this coupling. Both peaks follow transient elevation of BM norepinephrine and TNF secretion, which temporarily increase HSPC reactive oxygen species (ROS) levels. Lightinduced norepinephrine and TNF secretion augments HSPC differentiation and increases vascular permeability to replenish the blood. In contrast, darkness-induced TNF increases melatonin secretion to drive renewal of HSPCs and LT-HSC potential through modulating surface CD150 and c-Kit expression, increasing COX-2/alpha SMA(+) macrophages, diminishing vascular permeability, and reducing HSPC ROS levels. These findings reveal that light- and darkness-induced daily bursts of norepinephrine, TNF, and melatonin within the BM are essential for synchronized mature blood cell production and HSPC pool repopulation.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available