Journal
CELL STEM CELL
Volume 14, Issue 6, Pages 752-761Publisher
CELL PRESS
DOI: 10.1016/j.stem.2014.05.014
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Funding
- NIH Medical Scientist Training Program
- NIH [RO1-CA118750, RO1-ES023168]
- California Institute for Regenerative Medicine
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In recent years, long noncoding RNAs (IncRNAs) have emerged as an important class of regulators of gene expression. IncRNAs exhibit several distinctive features that confer unique regulatory functions, including exquisite cell-and tissue-specific expression and the capacity to transduce higher-order spatial information. Here we review evidence showing that lncRNAs exert critical functions in adult tissue stem cells, including skin, brain, and muscle, as well as in developmental patterning and pluripotency. We highlight new approaches for ascribing IncRNA functions and discuss mammalian dosage compensation as a classic example of an lncRNA network coupled to stem cell differentiation.
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