Journal
CELL STEM CELL
Volume 15, Issue 5, Pages 546-558Publisher
CELL PRESS
DOI: 10.1016/j.stem.2014.10.015
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Funding
- EMBO Long Term Postdoctoral Fellowship
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Understanding the molecular control of cell fates is central to stem cell research. Such insight requires quantification of molecular and cellular behavior at the single-cell level. Recent advances now permit high-throughput molecular readouts from single cells as well as continuous, noninvasive observation of cell behavior over time. Here, we review current state-of-the-art approaches used to query stem cell fate at the single-cell level, including advances in lineage tracing, time-lapse imaging, and molecular profiling. We also offer our perspective on the advantages and drawbacks of available approaches, key technical limitations, considerations for data interpretation, and future innovation.
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