Journal
CELL STEM CELL
Volume 14, Issue 6, Pages 710-719Publisher
CELL PRESS
DOI: 10.1016/j.stem.2014.05.008
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Funding
- EU Blueprint Epigenome Consortium
- Human Frontiers Science Program
- EU EpiGeneSys Network
- Wellcome Trust
- BBSRC
- BBSRC [BBS/E/B/000C0403, BBS/E/B/000C0400, BBS/E/B/0000H334, BBS/E/B/0000S266] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BBS/E/B/000C0403, BBS/E/B/000C0400, BBS/E/B/0000S266, BBS/E/B/0000H334] Funding Source: researchfish
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The inheritance of epigenetic marks, in particular DNA methylation, provides a molecular memory that ensures faithful commitment to transcriptional programs during mammalian development. Epigenetic reprogramming results in global hypomethylation of the genome together with a profound loss of memory, which underlies naive pluripotency. Such global reprogramming occurs in primordial germ cells, early embryos, and embryonic stem cells where reciprocal molecular links connect the methylation machinery to pluripotency. Priming for differentiation is initiated upon exit from pluripotency, and we propose that epigenetic mechanisms create diversity of transcriptional states, which help with symmetry breaking during cell fate decisions and lineage commitment.
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