Journal
CELL STEM CELL
Volume 14, Issue 6, Pages 701-703Publisher
CELL PRESS
DOI: 10.1016/j.stem.2014.05.007
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Funding
- NIGMS NIH HHS [R01 GM072744] Funding Source: Medline
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Derivation of motor neurons from human pluripotent stem cells is inefficient and requires complex culture protocols. Recently in Nature Materials, Sun et al. (2014) report that differentiating human pluripotent stem cells on soft substrates increases the efficiency of mature motor neuron differentiation by altering cytoskeletal mechanotransduction through the Hippo/YAP/Smad pathway.
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